This patient had a positive S. pneumoniae urine antigen. This test indicates that the patient suffered from an invasive infection that wasn’t detected with standard sputum or blood cultures. Previous to the initial test, antibiotics had been started for sepsis and had killed the causative pathogen in the standard sputum culture. When BioSherpa™ STS was used, it was able to release the causative pathogen from its protective biofilm for a proper diagnosis.