S. aureus was isolated from bone after weeks of antibiotic therapy using BioSherpa STS.
S. aureus was isolated from bone after weeks of antibiotic therapy using BioSherpa™ STS.
BioSherpa™ STS facilitated the detection of S. aureus persister cells in the infected bone sample, indicating incomplete treatment of the infection.
Surgical bone culture after weeks of effective antibiotics and normalization of inflammatory markers
The culture result on the left was the original isolate at the time of diagnosis.
The culture result on the right was taken after weeks of antibiotic therapy and normalization of inflammatory markers.
The same isolate was present based on the antibiotic susceptibility pattern. These results show that the organism was contained in a biofilm in the native bone and was coaxed out using BioSherpa™ STS. They also show that the antibiotic therapy failed and that further therapy and debridement was necessary. This information would not have been revealed using standard culture techniques.
Control had no growth.